Barriers to medical help-seeking among older men with prostate cancer

Objective:- Men's disinclination to seek medical help has been linked to higher rates of morbidity and mortality compared to women. However, previous studies were conducted predominantly with healthy, young, and middle-aged men. We explored the perceived medical barriers to help-seeking in older men with prostate cancer. Method:- 20 men with prostate cancer took part in semistructured interviews, which were analyzed using thematic analysis. Results:- Three themes were identified related to negative attitudes toward help-seeking: male gender role; fear of the health condition, medical and treatment procedures; and embarrassment as a consequence of medical examinations, communication with health (and nonhealth) professionals, and the disclosure of sexual-related symptoms. Conclusion:- The barriers identified in our study strengthen the evidence for the impact of traditional masculinity on help-seeking in men

Potassium-mediated zincation of ferrocene and ruthenocene : potassium, the architect behind supramolecular structural variations

Direct zincation of ferrocene and ruthenocene by the synergic base [PMDETA.K(μ-TMP)(μ-Me)Zn(Me)] produces the monozincated complexes [{PMDETA.K(μ-Me)2Zn(Fc)}∞] and [{PMDETA.K(μ-Me)2Zn(Rc)}2] respectively, having similar monomeric (dinuclear) units but aggregating supramolecularly in very different polymeric and dimeric forms

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease

The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage and represses alternative T cell fates. Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) that may be causative for autoimmune diseases. The majority of these polymorphisms are located within non-coding distal regulatory elements. It is considered that these genetic variants contribute to disease by altering the binding of regulatory proteins and thus gene expression, but whether these variants alter the binding of lineage-specifying transcription factors has not been determined. Here, we show that SNPs associated with the mucosal inflammatory diseases Crohn’s disease, ulcerative colitis (UC) and celiac disease, but not rheumatoid arthritis or psoriasis, are enriched at T-bet binding sites. Furthermore, we identify disease-associated variants that alter T-bet binding in vitro and in vivo. ChIP-seq for T-bet in individuals heterozygous for the celiac disease-associated SNPs rs1465321 and rs2058622 and the IBD-associated SNPs rs1551398 and rs1551399, reveals decreased binding to the minor disease-associated alleles. Furthermore, we show that rs1465321 is an expression quantitative trait locus (eQTL) for the neighboring gene IL18RAP, with decreased T-bet binding associated with decreased expression of this gene. These results suggest that genetic polymorphisms may predispose individuals to mucosal autoimmune disease through alterations in T-bet binding. Other disease-associated variants may similarly act by modulating the binding of lineage-specifying transcription factors in a tissue-selective and disease-specific manner

Análisis arqueosismológico del conjunto arqueológico romano de Mulva- Munigua (Sevilla, España). Resultados preliminares

El conjunto arqueológico romano de Mulva-Munigua (Sevilla, España) presenta daños en las edificaciones que pueden ser interpretadas como resultado de la ocurrencia de un evento sísmico (Efectos Arqueológicos de los Terremotos: EAEs) a finales del siglo III A.D., fecha coincidente con el inicio del periodo de declive económico de este asentamiento romano. Para intentar establecer el posible origen sísmico de las deformaciones, se ha procedido al inventario y análisis de las estructuras deformadas presentes en el yacimiento. No obstante, algunas de estas deformaciones también se pueden interpretar como resultado de procesos gravitaciones asociados a la ladera Este de la colina sobre la que se sitúa parte del yacimiento. Las direcciones de máxima deformación (ey) obtenidas del análisis de EAEs indica dos direcciones preferentes de la deformación (o movimiento preferente del terreno): NNO-SSE y ENEOSO. Aunque los datos presentan una dispersión importante, se puede establecer que la orientación principal NNO-SSE es compatible con un evento sísmico situado en el borde norte del Valle del Guadalquivir. La orientación ENE-OSO podría relacionarse con un evento posterior, o más seguramente con procesos de ladera de carácter cosísmico o no.The Roman archaeological site of Mulva-Munigua (Sevilla, Spain) displays building damage features suggesting a seismic origin (Earthquake Archaeological Effects: EAEs). The proposed seismic event could be tentatively dated in the late 3rd century AD, coinciding with the beginning of the economic fall of the Roman Empire at Iberia. However, some of the recorded EAEs can be also interpreted as a result of intervening slope movements in the eastern hillslope of this roman site. The inventory and analysis of the proposed EAEs make possible to discern between seismic oriented damage and other causes. In spite of the data show a significant dispersion, their analysis result in two different orientations of maximum deformation (ey) or preferential ground movement: NNW-SSE and ENE-WSW. The main ey orientation (NNW-SSE) can be tentatively related to a seismic event occurred in the environs of the northern border of the Guadalquivir Depression. The secondary orientation (ENE-WSW) can be interpreted as a consequence of latter slope movements triggered (or not) by other ancient earthquakes

65. Physical and clinical dosimetry by means of Monte Carlo using a process distribution tool

The choice of the most appropriate strategy in a Radiotherapy treatment is mainly based on the use of a planning system. With the introduction of new techniques (conformal and/or small fields, asymmetrical and non coplanar beams, true 3D calculations, IMRT) the trustworthiness of the algorithms is being questioned. An alternative verification procedure is every time more necessary to warranty a treatment delivery. The reliability of Monte Carlo is generally accepted. However, its clinical use has not been operative due to the high CPU times needed. During the last few years our objective has been focussed to reduce this time by means of new process distribution techniques. Tnis drop has made it feasible, not only the physical dosimetry under special conditions, but also a numerous variety of clinical cases: photon and electron conformal fields, Radiosurgery and IMRT. The carried out procedure is presented. Furthermore, experimental dosimetry data as well as conventional TPS calculations are compared with Monte Carlo simulations

Pre-Flight Calibration of the Mars 2020 Rover Mastcam Zoom (Mastcam-Z) Multispectral, Stereoscopic Imager

The NASA Perseverance rover Mast Camera Zoom (Mastcam-Z) system is a pair of zoomable, focusable, multi-spectral, and color charge-coupled device (CCD) cameras mounted on top of a 1.7 m Remote Sensing Mast, along with associated electronics and two calibration targets. The cameras contain identical optical assemblies that can range in focal length from 26 mm (25.5∘×19.1∘ FOV) to 110 mm (6.2∘×4.2∘ FOV) and will acquire data at pixel scales of 148-540 μm at a range of 2 m and 7.4-27 cm at 1 km. The cameras are mounted on the rover’s mast with a stereo baseline of 24.3±0.1 cm and a toe-in angle of 1.17±0.03∘ (per camera). Each camera uses a Kodak KAI-2020 CCD with 1600×1200 active pixels and an 8 position filter wheel that contains an IR-cutoff filter for color imaging through the detectors’ Bayer-pattern filters, a neutral density (ND) solar filter for imaging the sun, and 6 narrow-band geology filters (16 total filters). An associated Digital Electronics Assembly provides command data interfaces to the rover, 11-to-8 bit companding, and JPEG compression capabilities. Herein, we describe pre-flight calibration of the Mastcam-Z instrument and characterize its radiometric and geometric behavior. Between April 26thth and May 9thth, 2019, ∼45,000 images were acquired during stand-alone calibration at Malin Space Science Systems (MSSS) in San Diego, CA. Additional data were acquired during Assembly Test and Launch Operations (ATLO) at the Jet Propulsion Laboratory and Kennedy Space Center. Results of the radiometric calibration validate a 5% absolute radiometric accuracy when using camera state parameters investigated during testing. When observing using camera state parameters not interrogated during calibration (e.g., non-canonical zoom positions), we conservatively estimate the absolute uncertainty to be 0.2 design requirement. We discuss lessons learned from calibration and suggest tactical strategies that will optimize the quality of science data acquired during operation at Mars. While most results matched expectations, some surprises were discovered, such as a strong wavelength and temperature dependence on the radiometric coefficients and a scene-dependent dynamic component to the zero-exposure bias frames. Calibration results and derived accuracies were validated using a Geoboard target consisting of well-characterized geologic samples

Seismically induced liquefaction structures in La Magdalena archaeological site, the 4th century AD Roman Complutum (Madrid, Spain)

The ancient Roman city of Complutum(Alcalá deHenares,Madrid), founded in the 1st century AD,was one of the most important cities ofHispania. The old Roman citywas destroyed, abruptly abandoned, relocated close by and rebuilt during the late 4th century AD. Destruction of the city and its relocation has not yet been explained by archaeologists. In this paper,with ourmultidisciplinary approach, we identify and characterize earthquake archaeological effects (EAEs) affecting the archaeological site, the La Magdalena, an agricultural holding 4 km from the core of Complutum. The most important EAEs in the site are liquefactions (sand dikes and explosive sand-gravel craters) affecting Roman structures, such as water tanks (cisterns), houses and graves. Ground liquefaction generated significant ground cracks, explosive craters and folds in foundations of buildings. Several other Roman sites throughout the valleywere also abandoned abruptly during the 4th century AD, in some caseswith EAEs of similar origin. This suggests the occurrence of a 5.0–6.6 Mw seismic event in the zone, in accordance with the minimum empirical limit of seismically-induced liquefaction and the maximum surface rupture length of the Henares fault.Instituto Geológico y Minero de España, EspañaDepartamento de Geología, Escuela Politécnica Superior de Ávila, Universidad Salamanca, EspañaFacultad de Ciencias, Universidad Autónoma de Madrid, EspañaTrébede, Patrimonio Cultural, S.L., EspañaDepartamento de Ingeniería del Terreno, Escuela Politécnica Superior de Ávila, Universidad Salamanca, EspañaDepartamento de Edafología, Universidad Politécnica de Madrid, EspañaFacultad de Ciencias, Universidad Nacional de Educación a Distancia, EspañaDepartamento de Geología, Universidad de Alcalá de Henares, Españ

Estructuras de licuefacción sísmica en el yacimiento romano de La Magdalena, Complutum s. IV AD (Madrid, España)

la antigua ciudad romana de Complutum (Alcalá de Henares, Madrid) fue fundada en el s. I AD y fue una de las ciudades más importantes de Hispania. Complutum fue destruida, abandonada bruscamente, reubicada y reconstruida en una nueva localización en el s. IV AD. Las causas de la destrucción y la nueva localización de la ciudad son aún una incógnita para la arqueología. En este trabajo se muestran diferentes efectos arqueosismológicos de terremotos (EAEs) afectando al yacimiento de La Magdalena (una explotación agrícola situada a 4 km al NE del núcleo urbano de Complutum). El efecto geológico de origen sísmico que afectó al yacimiento es la licuefacción. Se pueden observar diques de arena y cráteres de gravas por explosión afectando a instalaciones romanas, como cisternas, casas o tumbas. Simultáneamente al abandono de La Magdalena también fueron abandonadas de forma brusca la ciudad de Complutum y varias villas romanas a lo largo del valle del Henares, en algunos casos con EAEs que pueden asociarse al mismo evento que destruyó el yacimiento de La Magdalena. Estos EAEs podrían estar generados por un terremoto de Mw = 5.0-6,6, utilizando los límites empíricos de licuefacción y ruptura cosísmica de la fallaInstituto Geológico y Minero de España, EspañaDepartamento de Geología, Escuela Politécnica Superior de Ávila, Universidad Salamanca, EspañaTrébede, Patrimonio Cultural, S.L., EspañaUniversidad de Salamanca, EspañaFacultad de Ciencias, Universidad Autónoma de Madrid, EspañaDepartamento de Ingeniería del Terreno, Escuela Politécnica Superior de Ávila, Universidad de Salamanca, EspañaDepartamento de Edafología, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, EspañaFacultad de Ciencias, Universidad Nacional de Educación a Distancia, EspañaDepartamento de Geología, Universidad de Alcalá de Henares, Españ